Computational Genomics with R 1st Edition

Description

After reading:

You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages.

You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data.

You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation.

You will know the basics of processing and quality checking high-throughput sequencing data.

You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites.

You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization.

You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq.

You will know basic techniques for integrating and interpreting multi-omics datasets.

Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.