Advances in Molecular Pathology, 2021 (Volume 4-1). \u00a0ORIGINAL PDF \/PRINT REPLICA<\/p>\n
This past year brought struggles and challenges to
\nthe entire world, including molecular diagnostic
\nlaboratories, due to the ongoing severe acute res-
\npiratory syndrome coronavirus 2 (SARS-CoV-2)
\npandemic. Overcoming supply chain issues affecting re-
\nagents, other consumables and disposables, along with
\nstaffing and equipment issues highlighted the impor-
\ntance of robust laboratory services as well as the ingenu-
\nity and creativity of laboratorians to meet those
\nchallenges head on. Polymerase chain reaction became
\na household term and the gold standard for viral detec-
\ntion. The laboratory-developed test in several varieties
\nonce again became the go-to assay that saved the day.
\nFrom diagnostic testing through screening and surveil-
\nlance testing and ultimately viral sequencing to detect
\nvariant strains of SARS-CoV-2, our laboratories deliv-
\nered on the unmet and uncertain needs of providers
\nand patients globally. At the time of this writing, coun-
\ntries have ramped up efforts to vaccinate individuals
\nwith one of several available vaccines, and in the United
\nStates, numbers of new cases and deaths due to COVID-
\n19 have significantly subsided. Globally, the virus con-
\ntinues to be a major cause of morbidity and mortality in
\nnumerous countries that have had delayed vaccination
\nresponses, and the potential resurgence of COVID-19
\ncases in those younger individuals that have yet to be
\nvaccinated remains a threat. Our hope is that continued
\nvaccination and mitigation strategies will end this
\npandemic if we remain vigilant and a new sense of
\n\u201cnormalcy\u201d will prevail.
\nIn this fourth issue of Advances in Molecular Pathology, we
\ninclude another special section on COVID-19 that high-
\nlights experiences from a laboratory perspective, sero-
\nlogic testing, and genomic surveillance of variants.
\nOur colleagues and authors found the time to shed light
\non some of the more interesting developments in the
\nfield of molecular pathology despite the burden that
\nthe pandemic has taken on all of us. Clinical genomics
\nis not a passing fad as some had predicted; it is here to
\nstay, and our stewardship of the testing on the analytical
\nand interpretative sides remains critical to patient care.
\nIn this issue, we review advances in the field of molecular pathology with regards to developments in
\ngenetic disease, hematologic disease, infectious disease,
\npharmacogenomics, solid tumors, and informatics.
\nSeveral articles present novel technologies, such as
\noptimal genome mapping, point-of-care diagnostics,
\nand artificial intelligence. Operationalizing genomic
\nmedicine in a clinical setting and assessing
\nminimal residual disease, cell-free nucleic acids,
\nand tumor mutation burden are discussed as impactful
\nstrategies in the management of the patient with cancer.
\nFinally, germline variants, nutrigenomics, and hyper-
\ntension are presented as new applications of
\npharmacogenomics.
\nI am grateful to those friends and colleagues who
\nonce again during the most pressing of times agreed
\nto become section editors and authors of the fantastic
\narticles presented here.
\nHappy reading!
\nGregory J. Tsongalis, PhD, HCLD
\nDepartment of Pathology and
\nLaboratory Medicine
\nDartmouth Hitchcock Medical Center
\n1 Medical Center Drive
\nLebanon, NH 03756, USA<\/p>\n","protected":false},"excerpt":{"rendered":"
Advances in Molecular Pathology, 2021 (Volume 4-1).<\/p>\n
FORMAT : ORIGINAL PDF \/PRINT REPLICA<\/p>\n
Publisher \u200f : \u200e\u00a0Elsevier (October 13, 2021)
\nPublication date \u200f : \u200e\u00a0October 13, 2021
\nLanguage \u200f : \u200e\u00a0English<\/p>\n","protected":false},"featured_media":8363,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":""},"product_cat":[393],"product_tag":[1755,1797,1672],"class_list":["post-8362","product","type-product","status-publish","has-post-thumbnail","hentry","product_cat-pathology-ebooks-and-videos","product_tag-infectious-medicine","product_tag-nutrition-books","product_tag-pathology"],"translation":{"provider":"WPGlobus","version":"3.0.2","language":"ca","enabled_languages":["en","uk","ar","au","ca","de","fr","es","pt","th","it","da","ko","he"],"languages":{"en":{"title":true,"content":true,"excerpt":true},"uk":{"title":false,"content":false,"excerpt":false},"ar":{"title":false,"content":false,"excerpt":false},"au":{"title":false,"content":false,"excerpt":false},"ca":{"title":false,"content":false,"excerpt":false},"de":{"title":false,"content":false,"excerpt":false},"fr":{"title":false,"content":false,"excerpt":false},"es":{"title":false,"content":false,"excerpt":false},"pt":{"title":false,"content":false,"excerpt":false},"th":{"title":false,"content":false,"excerpt":false},"it":{"title":false,"content":false,"excerpt":false},"da":{"title":false,"content":false,"excerpt":false},"ko":{"title":false,"content":false,"excerpt":false},"he":{"title":false,"content":false,"excerpt":false}}},"_links":{"self":[{"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/product\/8362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/comments?post=8362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/media\/8363"}],"wp:attachment":[{"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/media?parent=8362"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/product_cat?post=8362"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medicalebooks.org\/ca\/wp-json\/wp\/v2\/product_tag?post=8362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}