Nuclear Medicine and & Immunology (1st ed/1e 2022) First Edition

Nuclear Medicine and & Immunology (1st ed/1e 2022) First Edition PDF

CONTENTS

1 Introduction on Nuclear Medicine and Immunology . . . . . . . . . 1
Sara Harsini, Abass Alavi, and Nima Rezaei
2 Nuclear Imaging of Endogenous Markers of Lymphocyte
Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Israt S. Alam, Travis M. Shaffer, and Sanjiv S. Gambhir
3 Radioimaging of Activated T Cells in Preclinical
and Clinical Cancer Investigations . . . . . . . . . . . . . . . . . . . . . . . . 61
Áron Roxin and François Bénard
4 Gallium Imaging of Infection and Inflammation . . . . . . . . . . . . . 103
Mariza Vorster and Mike Sathekge
5 111Indium-Labeled Leukocyte Imaging of Infection
and Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Sara K. Meibom, Ilan Y. Benador-Shen,
and Gustavo A. Mercier
6 [
99mTc]Tc-HMPAO-Labeled Leukocyte Imaging of
Infection and Inflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Joanna E. Kusmirek and Scott B. Perlman
7 2-[18F]FDG PET Imaging of Infection and Inflammation . . . . . . 179
Ryogo Minamimoto
8 2-[18F]FDG PET/CT in Fever of Unknown Origin . . . . . . . . . . . . 209
Ilse J. E. Kouijzer, Chantal P. Bleeker-Rovers,
and Lioe-Fee de Geus-Oei
9 Tumor-Targeting Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
Dhritiman Chakraborty, Abhijit Das, and C. S. Bal
10 Tumor Architecture and Targeted Delivery . . . . . . . . . . . . . . . . . 237
Dhritiman Chakraborty, Abhijit Das, Meghana Prabhu,
Konudula Sreenivasa Reddy, Saurabh Arora, and C. S. Bal
11 Radionuclide Therapy and Immunomodulation . . . . . . . . . . . . . 249
Rachel Anderson and Katherine Vallis

12 Translational Development and Testing of Theranostics
in Combination with Immunotherapies . . . . . . . . . . . . . . . . . . . . 267
Peter M. Carlson and Zachary S. Morris
13 Radioimmunotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Majid Assadi and Ali Gholamrezanezhad
14 Radiolabeled Antibodies for Cancer
Radioimmunotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297
Julie Rousseau, Joseph Lau, and François Bénard
15 Dosimetric Principles of Targeted Radiotherapy
and Radioimmunotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347
Giuseppe De Vincentis, Viviana Frantellizzi,
and Massimiliano Pacilio
16 Theranostics of Hematologic Disorders . . . . . . . . . . . . . . . . . . . . 359
Arif Sheikh, Shazia Fatima, Zain Khurshid,
and Zaheer Chiragh
17 Radioimmunotherapy of Acute Leukemia . . . . . . . . . . . . . . . . . . 433
Roland B. Walter and Johnnie Orozco
18 Targeted Radionuclide Therapy and Immunotherapy
of Metastatic Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449
Hossein Jadvar
19 Radioimmunotherapy and Targeted Radiotherapy
of Squamous Cell Carcinoma of the Head and Neck . . . . . . . . . . 457
Siroos Mirzaei and Heying Duan
20 The Use of PET in Evaluating the Efficacy of
Immunotherapy in Oncology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 471
Judy Nguyen, Carina Mari Aparici, Sundeep Nayak, and
Benjamin L. Franc
21 Moving Forward: Expected Opportunities for the
Development of New Therapeutic Agents . . . . . . . . . . . . . . . . . . . 495
Philip F. Cohen, Tassia R. M. de Godoy, and Kalevi Kairemo

This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT).

Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future.

The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other.

Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.