The book “ESI manual of Endocrinology” provides in-depth knowledge of investigation and management of various endocrine disorders. The book is divided into eight sections. Section 1 on Diabetes and Metabolic syndrome addresses various types of diabetes through the ages, womens’ health, HIV, psychology, circadian rhythms and sleep, vitamin D, testosterone, metabolic syndrome and gut flora. Thyroid disorders are described in Section 2 with separate chapters on thyroid function tests hypothyroidism, hyperthyroidism, thyroid cancer and thyroid diseases in special situations. Section 3 addresses disorders of the pituitary and hypothalamus as well as a separate chapter on multiple endocrine neoplasia type 1. The entire spectrum of adrenal disorders is addressed in Section 4. Section 5 encompasses the bone and mineral disorders. Pubertal and reproductive endocrinologies are highlighted in Section 6, which covers amenorrhea, hypogonadism, PCOS and erectile dysfunction. Section 7 incorporates pediatric endocrinology with disorders of growth, puberty and sexual differentiation.