<\/p>\n
<\/p>\n
<\/p>\n
SECTION I
\nGLOBAL BURDEN OF NEUROLOGIC DISEASE 1
\nSection Editor: Mitchell S. V. Elkind
\n1 Worldwide Epidemiology of Neurologic Disease 1
\nJennifer Sevush-Garcy and Mitchell S. V. Elkind
\n2 Global Delivery of Neurologic Care 9
\nHiral Shah, Serena Spudich, and Kiran T. Thakur
\nSECTION II
\nAPPROACH TO THE NEUROLOGIC PATIENT 15
\nSection Editor: James M. Noble
\n3 Neurologic History Taking, Localization, and Differential
\nDiagnosis 15
\nJames M. Noble
\n4 The Neurologic Examination 25
\nJames M. Noble
\nSECTION III
\nCOMMON PROBLEMS IN NEUROLOGY 45
\nSection Editor: J. Kirk Roberts
\n5 Dizziness, Vertigo, and Hearing Loss 45
\nJ. Kirk Roberts
\n6 Syncope 51
\nTina T. Shih
\n7 Seizures 57
\nMichelle Bell, David J. Roh, and Jan Claassen
\n8 Pain, Numbness, and Paresthesias 64
\nComana M. Cioroiu
\n9 Headache and Facial Pain 70
\nAshhar S. Ali and Julio R. Vieira
\n10 Visual Disturbances 77
\nHeather E. Moss
\n11 Delirium 88
\nMerrick E. Miles, Christina J. Hayhurst, and
\nChristopher G. Hughes
\n12 Dementia and Memory Loss 95
\nLawrence S. Honig and James M. Noble
\n13 Involuntary Movements 103
\nSara M. Schaefer and Elan D. Louis
\n14 Muscle Weakness, Cramps, and Stiffness 110
\nComana M. Cioroiu
\n15 Gait Disorders 122
\nAshwini K. Rao
\n16 Acute Stroke: The First Hour 132
\nBarry M. Czeisler and Stephan A. Mayer
\n17 Acute Spinal Cord Syndromes 145
\nNatalie Weathered and Noam Y. Harel
\n18 Focal Mass Lesions 152
\nMichelle Bell, Alexander G. Khandji, and Fabio M. Iwamoto
\n19 Stupor and Coma 168
\nJan Claassen and John C. M. Brust
\n20 Brain Death 179
\nEelco F. M. Wijdicks
\nSECTION IV
\nDIAGNOSTIC TESTS 184
\nSection Editor: James M. Noble
\n21 Computed Tomography 184
\nPriya Shoor, Daniel S. Chow, and Angela Lignelli
\n22 Magnetic Resonance Imaging 189
\nEric Newman and Angela Lignelli
\n23 Positron Emission Tomography and Single-Photon Emission
\nComputed Tomography 203
\nWilliam Charles Kreisl
\n24 Neurovascular Ultrasound 208
\nTatjana Rundek
\n25 Angiography and Neuroendovascular Surgery 217
\nKatarina Dakay, Scott M. Woolf, Gurmeen Kaur,
\nDaniel H. Sahlein, and Fawaz Al-Mufti
\n26 Electroencephalography and Evoked Potentials 230
\nNicolas Gaspard and Emily J. Gilmore
\n27 Electromyography, Nerve Conduction Studies, and
\nMagnetic Stimulation 243
\nLouis H. Weimer
\n28 Autonomic Testing 255
\nLouis H. Weimer
\n29 Evaluation of the Special Senses (Vision, Hearing,
\nSmell, Vestibular System) 259
\nJ. Kirk Roberts
\n30 Sleep Studies 264
\nAndrew J. Westwood and Carl W. Bazil
\n31 Neuropsychological Evaluation 271<\/p>\n
32 Lumbar Puncture and Cerebrospinal Fluid Analysis 277<\/p>\n
Kiwon Lee<\/p>\n
33 Brain, Muscle, Nerve, and Skin Biopsy 283<\/p>\n
John F. Crary, Thomas H. Brannagan III, and Kurenai Tanji<\/p>\n
34 Intracranial Pressure and Neurocritical Care Monitoring 288<\/p>\n
Charles L. Francoeur and Stephan A. Mayer<\/p>\n
35 Genetic Testing and DNA Diagnosis 297<\/p>\n
Jill S. Goldman and Jacinda B. Sampson<\/p>\n
SECTION V<\/p>\n
CEREBROVASCULAR DISEASES 301<\/p>\n
Section Editor: Stephan A. Mayer<\/p>\n
36 Acute Ischemic Stroke 301<\/p>\n
Charles C. Esenwa and Stephan A. Mayer<\/p>\n
37 Transient Ischemic Attack 320<\/p>\n
Setareh Salehi Omran and Jose Gutierrez<\/p>\n
38 Hypoxic-Ischemic Encephalopathy 324<\/p>\n
Sachin Agarwal and Alexandra S. Reynolds<\/p>\n
39 Intracerebral Hemorrhage 332<\/p>\n
Stephan A. Mayer and Fred Rincon<\/p>\n
40 Subarachnoid Hemorrhage 342<\/p>\n
Stephan A. Mayer, Gary L. Bernardini, and<\/p>\n
Robert A. Solomon<\/p>\n
41 Cerebral Venous and Sinus Thrombosis 353<\/p>\n
Jennifer A. Frontera and Natalie Organek<\/p>\n
42 Vascular Malformations 361<\/p>\n
Fawaz Al-Mufti and Stephan A. Mayer<\/p>\n
43 Central Nervous System Vasculitis 370<\/p>\n
Kavneet Kaur, Hussein Alshammari, Ramandeep Sahni,<\/p>\n
Steven Marks, Stephan A. Mayer, and Fawaz Al-Mufti<\/p>\n
44 Posterior Reversible Encephalopathy Syndrome and<\/p>\n
Other Cerebrovascular Syndromes 384<\/p>\n
Claire S. Riley, Sara K. Rostanski, and Joshua Z. Willey<\/p>\n
45 Primary and Secondary Stroke Prevention 401<\/p>\n
Charles C. Esenwa and Mitchell S. V. Elkind<\/p>\n
SECTION VI<\/p>\n
NEUROTRAUMA 413<\/p>\n
Section Editor: Neeraj Badjatia<\/p>\n
46 Concussion and Chronic Traumatic Encephalopathy 413<\/p>\n
James M. Noble and John F. Crary<\/p>\n
47 Traumatic Brain Injury 420<\/p>\n
Gunjan Y. Parikh, Neeraj Badjatia, and<\/p>\n
Stephan A. Mayer<\/p>\n
48 Traumatic Spinal Cord Injury 441<\/p>\n
Christopher E. Mandigo, Michael G. Kaiser, and<\/p>\n
Peter D. Angevine<\/p>\n
49 Traumatic Cranial and Peripheral Nerve Injury 451<\/p>\n
Dominique M. O. Higgins, Lillian Liao,<\/p>\n
and Christopher J. Winfree<\/p>\n
SECTION VII<\/p>\n
DEMENTIA 469<\/p>\n
Section Editor: Karen S. Marder<\/p>\n
50 Mild Cognitive Impairment 469<\/p>\n
Lawrence S. Honig, Arash Salardini, William Charles Kreisl,<\/p>\n
and James M. Noble<\/p>\n
51 Alzheimer Disease 476<\/p>\n
Lawrence S. Honig and James M. Noble<\/p>\n
52 Frontotemporal Dementia 486<\/p>\n
Edward D. Huey, Megan S. Barker, and Stephanie Cosentino<\/p>\n
53 Lewy Body Dementias 492<\/p>\n
Oren Levy, Richard A. Hickman, and Karen S. Marder<\/p>\n
54 Vascular Dementia and Cognitive Impairment 500<\/p>\n
Nikolaos Scarmeas and Adam M. Brickman<\/p>\n
55 Prion Diseases 506<\/p>\n
Boon Lead Tee and Michael Geschwind<\/p>\n
SECTION VIII<\/p>\n
HEADACHE AND PAIN SYNDROMES 521<\/p>\n
Section Editor: Richard B. Lipton<\/p>\n
56 Primary and Secondary Headache Disorders 521<\/p>\n
Peter J. Goadsby and Richard B. Lipton<\/p>\n
57 Facial Pain Disorders and Painful Cranial Neuralgias 538<\/p>\n
Paul G. Mathew and Zahid H. Bajwa<\/p>\n
58 Complex Regional Pain Syndrome 549<\/p>\n
Steven P. Cohen, Michael L. Weinberger, and<\/p>\n
Thomas H. Brannagan III<\/p>\n
59 Neuropathic Pain 557<\/p>\n
Jeffrey Shije and Thomas H. Brannagan III<\/p>\n
SECTION IX<\/p>\n
EPILEPSY AND PAROXYSMAL DISORDERS 567<\/p>\n
Section Editor: Carl W. Bazil<\/p>\n
60 Classifi cation of Seizures and Epilepsy 567<\/p>\n
Shraddha Srinivasan and Carl W. Bazil<\/p>\n
61 Management of Epilepsy 578<\/p>\n
Carl W. Bazil and Shraddha Srinivasan<\/p>\n
62 M\u00e9ni\u00e8re Syndrome, Benign Paroxysmal Positional Vertigo, and<\/p>\n
Vestibular Neuritis 597<\/p>\n
Ian S. Storper<\/p>\n
63 Transient Global Amnesia 602<\/p>\n
John C. M. Brust<\/p>\n
SECTION X<\/p>\n
CENTRAL NERVOUS SYSTEM INFECTIONS 604<\/p>\n
Section Editor: Karen L. Roos<\/p>\n
64 Acute Bacterial Meningitis 604<\/p>\n
Brain, Spinal, and Epidural Abscess and Other Parameningeal
\nInfections 612
\nTracey A. Cho
\n66 Other Bacterial Central Nervous System Infections
\nand Toxins 624
\nKyle J. Coleman
\n67 Chronic Meningitis 640
\nPrashanth S. Ramachandran, Joseph R. Zunt,
\nKelly J. Baldwin, and Michael R. Wilson
\n68 Parasitic Infections 653
\nGustavo C. Rom\u00e1n
\n69 Viral Infections 661
\nShibani S. Mukerji, Maria Martinez-Lage, and
\nKiran T. Thakur
\n70 Human Immunodefi ciency Virus (HIV) and Acquired
\nImmunodefi ciency Syndrome (AIDS) 690
\nAnne Damian Yacoub, Deanna Saylor, Ned Sacktor,
\nKiran T. Thakur, Carolyn Barley Britton, and
\nBarbara S. Koppel
\nSECTION XI
\nDEMYELINATING AND INFLAMMATORY
\nDISEASES 711
\nSection Editor: David A. Hafl er
\n71 Multiple Sclerosis and Related CNS
\nNeuroimmune Diseases 711
\nErin E. Longbrake and Sarah F. Wesley
\n72 Transverse Myelitis 736
\nEoin P. Flanagan and Brian G. Weinshenker
\n73 Neuromyelitis Optica Spectrum Disorder 744
\nIris Vanessa Marin Collazo and Brian G. Weinshenker
\n74 Autoimmune Encephalitis and Meningitis 755
\nAndrew McKeon, Divyanshu Dubey, Eoin P. Flanagan,
\nAnastasia Zekeridou, and Sean J. Pittock
\n75 Neurosarcoidosis 773
\nSiddharama Pawate and Barney J. Stern
\nSECTION XII
\nMOVEMENT DISORDERS 778
\nSection Editor: Elan D. Louis
\n76 Essential Tremor 778
\nElan D. Louis
\n77 Tics and Tourette Syndrome 784
\nHarvey S. Singer
\n78 Restless Legs Syndrome 793
\nBrian B. Koo
\n79 The Dystonias 800
\nHyder A. Jinnah
\n80 Hemifacial Spasm 820
\nPaul Greene
\n81 Myoclonus 824
\nPichet Termsarasab and Steven J. Frucht
\n82 Hereditary and Acquired Ataxias 831
\nSheng-Han Kuo and Vikram G. Shakkottai
\n83 Tardive Dyskinesia and Other Neuroleptic-Induced
\nSyndromes 849
\nUn Jung Kang and Stanley Fahn
\n84 Choreas 854
\nRuth H. Walker and Joseph Jankovic
\n85 Huntington Disease 861
\nKaren S. Marder and Richard A. Hickman
\n86 Parkinson Disease 871
\nPeter LeWitt
\n87 Parkinson-Plus Syndromes 893
\nPaul Greene
\nSECTION XIII
\nNEUROMUSCULAR DISEASES 904
\nSection Editor: Thomas H. Brannagan III
\n88 Amyotrophic Lateral Sclerosis and Motor
\nNeuron Diseases 904
\nNeil A. Shneider
\n89 Bell\u2019s Palsy and Cranial Neuropathies 915
\nComana M. Cioroiu and Thomas H. Brannagan III
\n90 Mononeuropathies and Compression Neuropathies 927
\nThomas H. Brannagan III
\n91 Acquired Peripheral Neuropathies 936
\nThomas H. Brannagan III and Kurenai Tanji
\n92 Inherited Peripheral Neuropathies 955
\nChiara Pisciotta and Michael E. Shy
\n93 Myasthenia Gravis and Other Disorders of the
\nNeuromuscular Junction 963
\nChristina M. Ulane
\n94 Infl ammatory and Autoimmune Myopathies 979
\nRebecca Traub, Kurenai Tanji, and Christina M. Ulane
\n95 Critical Illness Myopathy and Neuropathy 989
\nAhmad Riad Ramadan, Michio Hirano, and
\nLouis H. Weimer
\n96 Endocrine and Toxic Myopathies 992
\nChristina M. Ulane
\n97 Periodic Paralysis and Other Channelopathies 998
\nComana M. Cioroiu
\n98 Stiff Person Syndrome and Peripheral Nerve and Muscle
\nHyperexcitability 1004
\nJonathan Perk and Christina M. Ulane
\n99 Metabolic and Mitochondrial Myopathies in Adults 1011
\nMichio Hirano, H. Orhan Akman, and
\nSalvatore DiMauro<\/p>\n
SECTION XIV<\/p>\n
NEUROONCOLOGY 1019<\/p>\n
Section Editor: Tobias Walbert<\/p>\n
100 Gliomas 1019<\/p>\n
J. Ricardo McFaline-Figueroa and Patrick Y. Wen<\/p>\n
101 Metastatic Tumors 1034<\/p>\n
Rupesh Kotecha and Minesh P. Mehta<\/p>\n
102 Meningiomas 1050<\/p>\n
Thomas J. Kaley<\/p>\n
103 Primary Central Nervous System Lymphoma 1056<\/p>\n
Lakshmi Nayak and Tracy T. Batchelor<\/p>\n
104 Tumors of the Pituitary Gland 1064<\/p>\n
Pamela U. Freda, John Ausiello, and Jeffrey N. Bruce<\/p>\n
105 Pineal Region Tumors 1072<\/p>\n
Jeffrey N. Bruce<\/p>\n
106 Acoustic Neuroma and Other Skull Base Tumors 1080<\/p>\n
Randy S. D\u2019Amico and Michael B. Sisti<\/p>\n
107 Spinal Tumors 1089<\/p>\n
David Cachia, Claudio E. Tatsui, and Mark R. Gilbert<\/p>\n
108 Paraneoplastic Syndromes 1100<\/p>\n
Erika Santos Horta and Tobias Walbert<\/p>\n
109 Complications of Cancer Therapy 1106<\/p>\n
Jasmin Jo and David Schiff<\/p>\n
SECTION XV<\/p>\n
HYDROCEPHALUS AND CEREBRAL<\/p>\n
EDEMA 1114<\/p>\n
Section Editor: Fred Rincon<\/p>\n
110 Hydrocephalus 1114<\/p>\n
Kumud Sharma and Fred Rincon<\/p>\n
111 Brain Edema and Increased Intracranial Pressure 1127<\/p>\n
Stephan A. Mayer<\/p>\n
112 Spontaneous Intracranial Hypotension 1139<\/p>\n
Kevin E. Immanuel, Tiffany R. Chang,<\/p>\n
and Kiwon Lee<\/p>\n
SECTION XVI<\/p>\n
SPINAL CORD DISORDERS 1145<\/p>\n
Section Editor: Paul C. McCormick<\/p>\n
113 Intervertebral Disk Disease and Radiculopathy 1145<\/p>\n
Hani Malone and Peter D. Angevine<\/p>\n
114 Cervical and Lumbar Spinal Stenosis 1153<\/p>\n
Brian J.A. Gill and Paul C. McCormick<\/p>\n
115 Acquired and Hereditary Myelopathies 1159<\/p>\n
Natalie Weathered and Noam Y. Harel<\/p>\n
SECTION XVII<\/p>\n
AUTONOMIC AND SLEEP DISTURBANCES 1170<\/p>\n
Section Editor: Louis H. Weimer<\/p>\n
116 Autonomic Failure, Autonomic Neuropathy, and<\/p>\n
Orthostatic Intolerance 1170<\/p>\n
Louis H. Weimer<\/p>\n
117 Paroxysmal Sympathetic Hyperactivity After Acute<\/p>\n
Brain Injury 1178<\/p>\n
Sophie Samuel and Huimahn Alex Choi<\/p>\n
118 Sleep Disorders 1183<\/p>\n
Andrew J. Westwood and Carl W. Bazil<\/p>\n
SECTION XVIII<\/p>\n
SYSTEMIC ORGAN FUNCTION AND THE<\/p>\n
NERVOUS SYSTEM 1195<\/p>\n
Section Editor: Kiwon Lee<\/p>\n
119 Heart-Brain Interactions 1195<\/p>\n
Shouri Lahiri and Stephan A. Mayer<\/p>\n
120 Sepsis-Associated Encephalopathy 1201<\/p>\n
Aur\u00e9lien Mazeraud, C\u00e1ssia Righy, Stephan A. Mayer,<\/p>\n
and Tarek Sharshar<\/p>\n
121 Respiratory Support for Neurologic Diseases 1207<\/p>\n
David B. Seder and Stephan A. Mayer<\/p>\n
122 Endocrine Diseases and the Brain 1215<\/p>\n
Spyridoula Tsetsou and Alexandra S. Reynolds<\/p>\n
123 Hematologic Diseases and the Brain 1227<\/p>\n
Andreas H. Kramer<\/p>\n
124 Hepatic Disease and the Brain 1245<\/p>\n
Charles L. Francoeur and Stephan A. Mayer<\/p>\n
125 Renal Disease, Electrolyte Disorders, and the<\/p>\n
Nervous System 1253<\/p>\n
J. Kirk Roberts and Stephan A. Mayer<\/p>\n
126 Gastric and Genitourinary Function and the Brain 1262<\/p>\n
Alden Doerner Rinaldi and Charles C. Esenwa<\/p>\n
127 Bone Diseases and the Central Nervous System 1270<\/p>\n
Roger N. Rosenberg and Alison M. Pack<\/p>\n
128 Malnutrition, Malabsorption, and Vitamin Defi ciencies 1277<\/p>\n
Rebecca Traub and Inna Kleyman<\/p>\n
129 Neurologic Disease During Pregnancy 1286<\/p>\n
Alison M. Pack<\/p>\n
130 Neurologic Complications of Organ Transplantation 1298<\/p>\n
SECTION XIX<\/p>\n
NEUROLOGIC TOXIDROMES 1303<\/p>\n
Section Editor: John C. M. Brust<\/p>\n
131 Alcoholism 1303<\/p>\n
John C. M. Brust<\/p>\n
132 Drug Intoxication and Withdrawal 1313<\/p>\n
John C. M. Brust<\/p>\n
133 Neurotoxicology 1319<\/p>\n
Christopher Zammit and Stephan A. Mayer<\/p>\n
134 Radiation Injury 1335<\/p>\n
Matthew R. Leach and Christopher Zammit<\/p>\n
135 Electrical and Lightning Injury 1347<\/p>\n
Imad Khan and Christopher Zammit<\/p>\n
136 Decompression Illness 1350<\/p>\n
Matthew R. Leach and Christopher Zammit<\/p>\n
SECTION XX<\/p>\n
PEDIATRIC NEUROLOGY 1355<\/p>\n
Section Editor: Arthur M. Mandel<\/p>\n
137 Neonatal Neurology 1355<\/p>\n
Arthur M. Mandel<\/p>\n
138 Nervous System Formation and Malformation 1366<\/p>\n
Gary D. Clark<\/p>\n
139 Inherited Metabolic Diseases 1385<\/p>\n
Marc C. Patterson<\/p>\n
140 Chromosomal Disorders and Disorders of DNA 1410<\/p>\n
Marc C. Patterson<\/p>\n
141 The Floppy Infant 1417<\/p>\n
Maryam Oskoui, Laurent Servais, and<\/p>\n
Darryl C. De Vivo<\/p>\n
142 Disorders of Motor and Cognitive Development 1424<\/p>\n
Jason B. Carmel, Toni S. Pearson, and Reet Sidhu<\/p>\n
143 Autism Spectrum Disorders 1433<\/p>\n
Sylvie Goldman and Jennifer M. Bain<\/p>\n
144 Mitochondrial Encephalomyopathies 1441<\/p>\n
Salvatore DiMauro, Emanuele Barca, and<\/p>\n
Michio Hirano<\/p>\n
145 Neurocutaneous Syndromes 1456<\/p>\n
Marc C. Patterson<\/p>\n
146 Spinal Muscular Atrophies of Childhood 1467<\/p>\n
Basil T. Darras, Richard S. Finkel, and Darryl C. De Vivo<\/p>\n
147 Muscular Dystrophies and Congenital Myopathies 1474<\/p>\n
James J. Dowling, Hernan D. Gonorazky, Dimah N. Saade,<\/p>\n
Michael W. Lawlor, and Darryl C. De Vivo<\/p>\n
148 Seizures and Epilepsies in Neonates and Children 1502<\/p>\n
Tristan T. Sands and M. Roberta Cilio<\/p>\n
149 Pediatric Stroke 1515<\/p>\n
Sally M. Sultan and Robert H. Fryer<\/p>\n
150 Brain Tumors in Children 1528<\/p>\n
James H. Garvin, Jr<\/p>\n
151 Pediatric Brain Injury and Shaken Baby Syndrome 1572<\/p>\n
Joshua Cappell and Steven G. Kernie<\/p>\n
152 Human Immunodefi ciency Virus, Fetal Alcohol Syndrome,<\/p>\n
and Drug Effects 1579<\/p>\n
Claudia A. Chiriboga<\/p>\n
SECTION XXI<\/p>\n
PSYCHIATRY AND NEUROLOGY 1588<\/p>\n
Section Editor: David H. Strauss<\/p>\n
153 Psychosis 1588<\/p>\n
Jacob S. Ballon and T. Scott Stroup<\/p>\n
154 Mood Disorders 1596<\/p>\n
Andr\u00e9s Barrera, Lic\u00ednia Ganan\u00e7a, Alejandro S. Cazzulino,<\/p>\n
and Maria A. Oquendo<\/p>\n
155 Anxiety Disorders, Posttraumatic Stress Disorder, and<\/p>\n
Obsessive-Compulsive Disorder 1606<\/p>\n
Franklin R. Schneier<\/p>\n
156 Somatic Symptom Disorders 1615<\/p>\n
Anna L. Dickerman, Philip R. Muskin, and Vivian Liu<\/p>\n
SECTION XXII<\/p>\n
RECOVERY AND END-OF-LIFE CARE 1629<\/p>\n
Section Editor: Joel Stein<\/p>\n
157 Neurologic Rehabilitation 1629<\/p>\n
Joel Stein and Heidi Schambra<\/p>\n
158 End-of-Life and Palliative Care in Neurology 1636<\/p>\n
Tobias Walbert, Fred Rincon, and James M. Noble<\/p>\n
Index 1645<\/p>\n","protected":false},"excerpt":{"rendered":"
Merritt\u2019s Neurology Fourteenth Edition 14th ed PDF by Elan D. Louis MD MS (Author), Stephan A. Mayer MD (Author), Dr. James M. Noble MD MS CPH FAAN (Author)<\/p>\n
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\nLanguage \u200f : \u200e English
\nISBN-10 \u200f : \u200e 1975141229
\nISBN-13 \u200f : \u200e 978-1975141226<\/p>\n
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