Cell Biology of Trauma

MECHANISMS OF LETHAL CELL INJURY
Chapter 1
Models of Toxicity Screening Using Cultured Cells………………………………….3
Roberta L. Grant and Daniel Acosta, Jr.
Chapter 2
Apoptosis: Cellular Signaling and Molecular Mechanisms………………………25
Rosemary B. Evans and John A. Cidlowski
Chapter 3
Role of Mitochondrial Injury during Oxidative Injury to
Hepatocytes: Evidence of a Mitochondrial Permeability Transition
by Laser Scanning Confocal Microscopy……………………………………………….. 49
Anna-Liisa Nieminen, Roberto Imberti, Alice K. Saylor,
Samuel A. Tesfai, Brian Herman, and John J. Lemasters
CYTOPROTECTIVE STRATEGIES
Chapter 4
Glycine Cytoprotection and Inhibition of Nonlysosomal
Calcium Dependent Proteolysis during Anoxic Injury of
Rat Hepatocytes………………………………………………………………………………………65
J. Christopher Nichols, Rolland C. Dickson, Steven F. Bronk,
and Gregory J. Gores
Chapter 5
Di-Calciphor-Dependent Protection against Cell Death due
to Mitochondrial Failure………………………………………………………………………… 79
Dean P. Jones
Chapter 6
Role of the Mitochondrial ATPase Inhibitor, IF1? in
Cytoprotection during Ischemia in Slow and Fast Heart Rate H earts 87
William Rouslin and Charles W. Broge
Chapter 7
The Discovery and Pharmacology of Tirilazad Mesylate………………………. 105
John M. McCall

ISCHEMIA/REPERFUSION INJURY
Chapter 8
The Role of Neutrophils and Reactive Oxygen Metabolites
in Reperfusion Injury…………………………………………………………………………….117
Barbara J. Zimmerman and D. Neil Granger
Chapter 9
The Inflammatory Response after HepaticIschemia/Reperfusion 127
Hartmut Jaeschke
Chapter 10
The pH Paradox in Reperfusion Injury to Heart Cells…………………………..149
John J. Lemasters, John M. Bond, Ian S. Harper, Enrique Chacon,
Hisayuki Ohata, Brian Herman, and Wayne E. Cascio
Chapter 11
Pathophysiology of Spinal Cord Injury in a Rat Model of
Decompression Sickness………………………………………………………………………. 163
Louis Marzella
STRESS RESPONSE AND WOUND HEALING
Chapter 12
The Stress Response and Stress Proteins……………………………………………….177
Martin E. Feder, Dawn A. Parsell, and Susan L. Lindquist
Chapter 13
Cross Talk between Heat Shock and Oxidative Stress Inducible
Genes during Myocardial Adaptation to Ischemia………………………………….193
Dipak K. Das and Nilanjana Maulik
Chapter 14
Alteration in Cell Cycle Control Factors and the Induction of
Oxygen Regulated Proteins by Hypoxic Stress……………………………………..213
Harold C. Smith, Robert L. Howell, and John W. Ludlow
Chapter 15
Stress Proteins in Renal Ischemia…………………………………………………………. 227
Shirley Hilden

Chapter 16
Human Keratinocyte Migration Involves Extracellular Matrix
and Soluble Factors……………………………………………………………………………..251
David T. Woodley, John D. Chen, Elizabeth Shim, Janice P. Kim,
Jean-Christophe Lapiere, and Christina Peavey
Chapter 17
Endothelial Cell Signaling during Wound Healing……………………………….. 259
Lewis H. Romer
PRESERVATION OF CELLS AND ORGANS
Chapter 18
Development and Optimization of Preservation Solutions…………………….. 289
James H. Southard
Chapter 19
Hypoxia, Free Radicals, and Reperfusion Injury Following
Cold Storage and Reperfusion of Liversfor Transplantation…………………..299
Ronald G. Thurman, Wenshi Gao, Henry D. Connor,
Sigrid Bachmann, Robert T. Currin, Ronald P. Mason, and
John J. Lemasters
Chapter 20
Cellular Injury Associated with Organ Cryopreservation:
Chemical Toxicity and Cooling Injury…………………………………………………. 333
Gregory M. Fahy, Carla da Mouta, Latchezar Tsonev,
Bijan S. Khirabadi, Patrick Mehl, and Harold T. Meryman
Index…………………………………………………………………………………………………….357